Our friendly gut bacteria, Parabacteroides distasonis (P. distasonis for short), might just save the day for those with liver fibrosis! You see, scientists have discovered that this little microbial helper plays a big role in our health, and it’s often found in lower amounts in people with liver fibrosis.
When researchers gave P. distasonis to mice with liver fibrosis, their condition improved! The gut bacteria helped regulate bile acids, ultimately decreasing a toxic bile acid called TCDCA in the liver. Too much TCDCA can damage liver cells and lead to fibrosis.
And the best part? The study found that a natural compound called celastrol can boost P. distasonis levels in mice, making it a potential liver-fibrosis-fighting superhero! So, it turns out that taking care of our gut buddies might be an exciting new way to help improve liver health. Who knew our microscopic friends could be so powerful?
https://doi.org/10.1038/s41467-023-37459-z
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