Recent research on mice suggests that the gut microbiome may play an important role in the development of Alzheimer’s disease. This devastating condition is characterized by cognitive dysfunction, as well as brain tissue and neuron loss, which has been linked to a buildup of a protein called tau. When compared to conventionally raised mice, germ-free mice had fewer neurons and less tissue loss in key brain regions, as well as less tau buildup. Interestingly, when conventionally reared mice were given antibiotics to kill their gut bacteria, this treatment reduced brain atrophy in male mice, but not in female mice. Although more research is needed to understand the effects of the microbiome on Alzheimer’s risk in humans, this study provides new insights into the potential role of the gut microbiome in this condition.

https://doi.org/10.1126/science.add1236


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